Generic name
cefoperazone sodium for injection
Description
cefoperazone sodium is a white or off-white crystalline powder which is deliquescent, odorless, and easy to absorb water.
Indication
It is indicated for the treatment of following infections when caused by susceptible organism: pneumonia and other infections in sites of liver respiratory tract, urinary tract, biliary tract, skin and soft tissue, blood poisoning, peritonitis and abdominal cavity infection, the later two infections is preferred to use jointly with anti anaerobic bacterium.
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Dosage and administration
Cefoperazone sodium can be administered by intravenous injection. Intravenous instillation or intramusclar injection. The usual adult daily dose of cefoperazone sodium is 1-2g(half piece-1piece) every 12 hours each time to general infection, 2-3g(1piece-one and a half pieces) every 8 hours each time to severe infections. To the patients receiving hemodialysis, an administration should be added. The adult daily dose shouldn’t exceed 9g(4 and half pieces). To immunity deficient patient with severe infection, the dose can be increased to 12g(6pieces). Common dose for children is 50-200mg/kg per day which is divided into 2-3 administrations by intravenous drip. To form 250mg/ml intramuscularly injection solution, every 1g (half piece) injection should be dissolved into 2.8ml sterile water for injection and 1g of 12% lidocaine hydrochloride injection.to form slow intravenous injection,1g injection should be dissolved into 40ml dextrose sodium chloride injection solution, for intravenous drip, the last drug concentration is 5-25mg/ml following1-2g(one and a half and 1pieces) cefoperazone sodium for injection diluted into 100-200ml dextrose sodium chloride injection or other diluted solution. The last drug concentration is 5-25mg/ml. The content of Na is 1.5mol(34mg)per 1g cefoperazone sodium.
Side effects
1 the exanthem is common, counting for 2.3%or even more.
2 few patients even experience diarrhea, stomachache, increase of eosinophil and decrease of mild neutrophil.
3temporary increase of serum aminotransforace, urea hydrogen and blood creatinine.
4 the decrease of blood placlet and prolong of thrambin may seldom occur, and vitamin k can be taken to precaution or control bleeding.
5 few patients may experience bacteria imbalance
6 disulfiran reactions may occur in patients during alcohol or beverage.
Contradictions
Cefoperazone sodium is contradicted to patients allergic to cephalosporin class, with allergic shock to penicillin or with instant reaction history to penicillin.
Precautions
1. This medicine has a good effect to treat infant infection, but there is still lack information for research of newborn and premature.
2. The interference with diagnosis: it may appear false positive when executing a determination through bluestone, and may appear positive in a direct coombs experiment. The newbone may also appear positive. And the sgpt, serum aspartate transaminase, serum creatimine and hematuria hitrogen may seldom increase.
3. To the patient with hepatiosis and biliary tract obstruction, the t1/2 prolong and the cefoperazone excretion in the urine will increase, but to the patient with serious hepaoisis or biliary tract obstruction, there are still effective treating concentration in the bile, the dose should be adjusted and the serum concentration should be monitored. The dose can’t exceed 2g if the serum concentration can’t be monitored.
4. The lack of vitamin k and hypoprothrombinemia may appear in some patients, so should monitor the bleeding period and the thrombin time. And the vitamin k can be used to prevent bleeding.
5. It may cause double infections if use cefoperazone for a long run.
6. Chiasma infection: the patient sensitive to any kind of cephalothin sensitive to this medicine.
Usage for pregnancy and women during lactation
There are a few cefoperazone in the milk, the woman in lactation should stop suckle.
Usage for children
It should be cautious when newborn and premature use this medicine.
Drug interaction
1. When this product is used combined with aminoglycoside antibiotics (gentamycin and tobramycin) , the synergistic action will occur when meet some sensitive strain of enterobacter or aeruginosin pseudomonas.
2. The product may cause hypothrombinogen and decrease of blood platelet, it may cause bleed when mixed with following drugs: anticoagnlatine drug cnmarin or strepto drugs to diminish inflammations(such as aspirin, diflunisal or other salicylic acid preparation.) and sulfinpyrazone.
3. Methylthizole lateral chain is contained in this chemical structure. Drink or injected alcohol may result in restraining the activity of acetat dehyckdehy-drogenase; cause the accumulation of the aldehyde in the blood; cause the lethargy hallucination and other disulfiram reaction. So the patient should not drink eat or inject drugs contain ethyl alcohol.
4 the medicine can’t mix with aminoglycoside antibiotic for instillation, because of the influence to the antibiotic activity between each other.
5 the medicine is contradicted to mixed with following drugs: amikacin, cidomycin, kanamycin, doxycycline meclofenoxate aritmina amidryl aparagin hydroxyzine procaine amide cardiofilina hematin roktein pentazocine and aprotinin.
The overdose of the drug:
There are not very effective drugs to counteract this medicine, so the patient should be treated according to the disease and supplied plenty water and fluid.
Storage
Airtight and preserve coolly
Package
In ampoule, and one ampoule per box.
Period of Validity
2 years |
